Associate Scientist - iPSC-Derived Neuron Models
12 month contract
On-site in Lexington, MA
Must be able to work on a W2
JOB DESCRIPTION:
Position Summary:
We are seeking a highly motivated and detail-oriented scientist to join our Humanized In Vitro Model Development team. The successful candidate will contribute to the development of human iPSC-derived neuronal models and assays to support drug discovery and translational research. This is an exciting opportunity to work at the forefront of human-relevant neuroscience in a collaborative and innovative environment.
TOP SKILLS:
1. Human iPSC-derived neuron culture experience
2. Gene perturbations using siRNA and/or CRISPR
3. Cell-based molecular and biochemical assays including 1) immunocytochemistry, 2) qPCR, 3) ELISA, 4) micro-electrode array (MEA), and 5) fluorescence microscopy (at least 2-3 of these 5 skillsets).
Key Responsibilities:
• Culture, differentiate, and maintain human iPSC-derived neurons.
• Perform routine cell-based and molecular assays including immunocytochemistry, qPCR, ELISA, MEA, luciferase, western blot, and fluorescence microscopy.
• Conduct functional gene perturbations and pharmacological interventions.
• Support assay development and optimization for phenotypic screening and mechanistic studies.
• Analyze and interpret experimental data, maintain accurate records, and present findings in team meetings.
• Collaborate cross-functionally with scientists in different units.
• Contribute to protocol development, SOP documentation, and continuous improvement initiatives.
Qualifications:
• Bachelor’s or Master’s degree in Neuroscience, Cell Biology, Stem Cell Biology, or a related field.
• LEVEL II - Minimum of 2 years of hands-on experience with human iPSC-derived neuronal cell models and assays.
• LEVEL III - Minimum of 5 years of hands-on experience with human iPSC-derived neuronal cell models and assays.
• Proficiency in cell-based assay techniques and fluorescence microscopy.
• Strong organizational and communication skills.
• Ability to work independently and collaboratively in a fast-paced research environment.
• Comfortable working with electronic lab notebooks.
Preferred Skills:
• Experience with CRISPR editing, RNA-seq, calcium imaging, high-content imaging, or complex co-culture systems is plus.
• Knowledge of automated liquid handling systems and high-throughput screening platforms.
• Familiarity with cardiometabolic diseases is a plus.
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