Job Description
Yoh is looking for a skilled and driven
Senior Research Scientist, Biophysics with hands-on experience in small molecule drug discovery to join our collaborative Lead Discovery team. This is a lab-based role focused on the biophysical and mechanistic characterization of small molecule-protein interactions to support our drug discovery pipeline.
Industry : Discovery and Development
Location : South San Francisco, CA
Key Responsibilities: - Design and execute binding characterization studies using SPR (Biacore S200 and 8K+).
- Conduct routine compound screening and mechanistic studies using biophysical assays (e.g., nanoDSF, DLS, Spectral Shift).
- Manage and coordinate outsourced biophysical studies with CROs.
- Analyze and interpret data to support SAR and lead optimization across multiple projects.
- Maintain detailed experimental records and present findings in internal meetings and reports.
Qualifications: - PhD in Biophysics, Biochemistry, or a related field.
- Minimum 3 years of relevant experience in small molecule drug discovery biophysics (industry or academic).
- Proven expertise in SPR assay development and data interpretation.
- Demonstrated expertise in designing, developing, and interpreting biophysical characterization of small molecule-protein interactions by SPR.
- Strong familiarity with additional biophysical techniques (TSA, DLS, Spectral Shift, NMR, ITC, etc.).
- Proficiency with data analysis and graphing tools is a plus.
Ideal Candidate Attributes: - Critical thinker with the ability to integrate complex data and communicate insights clearly.
- Thrives in a fast-paced, collaborative environment.
- Proactive in identifying challenges and implementing solutions.
- Passionate about science and making a meaningful impact.
- Contributes positively to team culture and company values.
#IND-SPG
Estimated Min Rate : $70.00
Estimated Max Rate : $80.00 What’s In It for You?
We welcome you to be a part of the largest and legendary global staffing companies to meet your career aspirations. Yoh’s network of client companies has been employing professionals like you for over 65 years in the U.S., UK and Canada. Join Yoh’s extensive talent community that will provide you with access to Yoh’s vast network of opportunities and gain access to this exclusive opportunity available to you. Benefit eligibility is in accordance with applicable laws and client requirements. Benefits include:
- Medical, Prescription, Dental & Vision Benefits (for employees working 20+ hours per week)
- Health Savings Account (HSA) (for employees working 20+ hours per week)
- Life & Disability Insurance (for employees working 20+ hours per week)
- MetLife Voluntary Benefits
- Employee Assistance Program (EAP)
- 401K Retirement Savings Plan
- Direct Deposit & weekly epayroll
- Referral Bonus Programs
- Certification and training opportunities
Note: Any pay ranges displayed are estimations. Actual pay is determined by an applicant's experience, technical expertise, and other qualifications as listed in the job description. All qualified applicants are welcome to apply.
Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
Visit to contact us if you are an individual with a disability and require accommodation in the application process.
For California applicants, qualified applicants with arrest or conviction records will be considered for employment in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act. All of the material job duties described in this posting are job duties for which a criminal history may have a direct, adverse, and negative relationship potentially resulting in the withdrawal of a conditional offer of employment.
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